The role of SRC-3 in estrogen-dependent vasoprotection during vascular wall remodeling postinjury
نویسنده
چکیده
Estrogen receptors are hormone-inducible transcription factors requiring coactivators such as members of the SRC/p160 family to modulate the transcription of their target genes. This perspective will examine the interplay between estrogen receptors and their coactivators in vasoprotection during vascular wall remodeling.
منابع مشابه
Steroid receptor coactivator-3 is required for inhibition of neointima formation by estrogen.
BACKGROUND The vasoprotective effects of estrogen are mediated by estrogen receptors (ERs). ERs are transcription factors that require coactivators to exert transcriptional activity. The steroid receptor coactivator-3 (SRC-3, also known as pCIP, AIB1, ACTR, and TRAM-1) interacts with estrogen-bound ERs and strongly coactivates the transcription of target genes in cultured cells. This study has ...
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OBJECTIVE The steroid receptor coactivator-1 (SRC-1) is a transcriptional coactivator for nuclear receptors including estrogen receptor (ER). SRC-1 can interact with ER in an estrogen binding-dependent manner to potentiate the transcriptional activity of ER. Previous studies showed that SRC-1 was required for the full function of ER in cultured cells and in the reproductive system. In this stud...
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ورودعنوان ژورنال:
- Nuclear Receptor Signaling
دوره 1 شماره
صفحات -
تاریخ انتشار 2003